sccloud.diffmap

sccloud.diffmap(data, n_components=100, rep='pca', solver='eigsh', random_state=0, max_t=5000)[source]

Calculate Diffusion Map.

Parameters

  • data (anndata.AnnData) – Annotated data matrix with rows for cells and columns for genes.

  • n_components (int, optional, default: 100) – Number of diffusion components to calculate.

  • rep (str, optional, default: "pca") – Embedding Representation of data used for calculating the Diffusion Map. By default, use PCA coordinates.

  • solver (str, optional, default: "eigsh") –

    Solver for eigen decomposition:

    • "eigsh": default setting. Use scipy eigsh as the solver to find eigenvalus and eigenvectors using the Implicitly Restarted Lanczos Method.

    • "randomized": Use scikit-learn randomized_svd as the solver to calculate a truncated randomized SVD.

  • random_state (int, optional, default: 0) – Random seed set for reproducing results.

  • max_t (float, optional, default: 5000) – scCloud tries to determine the best t to sum up to between [1, max_t].

Return type

None

Returns

  • None

  • Update data.obsm –

    • data.obsm["X_diffmap"]: Diffusion Map matrix of the data.

  • Update data.uns –

    • data.uns["diffmap_evals"]: Eigenvalues corresponding to Diffusion Map matrix.

Examples

>>> scc.diffmap(adata)